ࡱ> {7 YbjbjUU 7|7|sl444HXXX8$LHxP||"&&&OOOOOOOR 2sigma(I)] R1 = 0.0362, wR2 = 0.0737 R indices (all data) R1 = 0.0571, wR2 = 0.0819 Absolute structure parameter 0.016(10) Largest diff. peak and hole 0.353 and -0.294 e.-3 Table 3. Atomic coordinates ( x 104) and equivalent isotropic displacement parameters (2x 103) for p-Bromobenzoate 12 U(eq) is defined as one third of the trace of the orthogonalized Uij tensor. ________________________________________________________________________ x y z U(eq) ________________________________________________________________________ Br(1) 2607(1) 9274(1) 2612(1) 53(1) Br(2) -2964(1) 1334(1) 4681(1) 65(1) O(1) -220(3) 7164(4) 88(3) 47(1) O(2) 2483(3) 9358(5) 276(2) 63(1) O(3) -714(3) 7714(3) 3627(2) 39(1) O(4) -2834(4) 8307(4) 4095(3) 51(1) O(5) -2122(3) 9971(3) 1268(3) 42(1) O(6) -2186(3) 7646(3) 1721(2) 36(1) C(1) 1064(4) 9008(4) 1688(3) 35(1) C(2) 1394(4) 8991(5) 563(3) 40(1) C(3) 303(4) 8501(5) -191(3) 38(1) C(4) -1061(4) 8342(5) 187(3) 37(1) C(5) -1413(4) 8699(4) 1297(3) 34(1) C(6) -186(4) 8891(4) 2051(3) 32(1) C(7) -516(5) 9059(5) 3176(3) 40(1) C(8) -1967(5) 7448(5) 3997(3) 38(1) C(9) -2128(5) 5980(4) 4226(3) 36(1) C(10) -3384(5) 5549(5) 4569(4) 42(1) C(11) -3640(5) 4169(6) 4718(3) 44(1) C(12) -2632(5) 3229(5) 4533(4) 42(1) C(13) -1372(5) 3647(5) 4229(4) 44(1) C(14) -1120(5) 5022(5) 4081(4) 41(1) C(15) -3557(4) 9865(5) 1473(4) 43(1) C(16) -4168(5) 8700(6) 832(5) 51(1) C(17) -3451(4) 7341(6) 1110(4) 45(1) C(18) -4237(6) 6423(9) 1814(5) 61(2) C(19) -4161(6) 11250(9) 1219(6) 66(2) C(20) 547(6) 8683(8) -1350(4) 52(1) C(21) -612(5) 8203(6) -2047(4) 49(1) C(22) -1645(5) 8939(5) -2404(3) 43(1) C(23) -1850(6) 10421(6) -2162(5) 62(2) C(24) -2785(7) 8313(7) -3110(5) 78(2) X-ray Crystal Structure of p-Bromobenzoate 12  Experimental Section for antifungal assays Minimum inhibitory concentrations (MICs) against various plant pathogens were determined by preparing a stock solution of each compound (1 mg mL -1 in MeOH). This was dispensed, by serial 2-fold dilution, into a 24-well plate. Each well of the plate contained 1000 L of potato dextrose broth. A small plug of the test fungus was placed into each well and the plate incubated for 48 h at 23 oC. The MIC was taken as the concentration of the compound in the well where no growth visually appeared after 48 h. Experimental Section for tumor cell assays Human cell lines HL-60 and U-937 (leukemia) and MDA- MB-231 (breast cancer) were obtained from ATCC (Rockville, MD.). The cells were maintained at 37C and 5% CO2 in a humidified incubator in RPMI media supplemented with 10% fetal bovine serum. The cells were exposed to serial dilutions of candidate compounds for 64-70 h. Cytotoxic activity was measured by a colorimetric assay based on the enzymatic cleavage of XTT to a water-soluble formazan product (Journal Immunological Methods, 142:257-265 (1991). Reference for the XTT assay: Neal W. Roehm, George H. Rogers, Stephen M. Hatfield and Andrew L. 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B~xjxOle PRINT.0VGVjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8  LF p5$$$$xf  `  xXX Pe(XX dd'`Kp}/ArialPKp}/$$PJM qs̊7KM rsl̊7LM ss7MM tslz701mPiMqMjMNM usz701lPjMkMOM v 701yMkMlMxMPM wsQM x `Oŕ9Ƽ7+RM yݿ1~7SM zsR~TM {`BrمΒ&1Jv7#+UM |#SrVM }`OTBDPSy#;vIMAu7PuP ~ LrP  `O2nIʡoJv7+vP nM^7wP ^eP `Sif^e8ObISi7+xP )U7yP nMXP7zP ܺ+,I7{P K(XP7|P K(^7}P ܺ_e7~P 2U7P JI7P 2<7P )<7P JI7P #53o7P Wb7P J`v7P {7P  7P PuP P uPwP P vPwP P wPxP P vPyP  PPPP yPzP P zP{P  PPP {P|P P |P}P  PPP vP}P P xP~P  PPPP ~PP P PP  PPP PP P PP  PPP xPP P wPP P PP P PP P PP WM s7XM sll7YM s7ZM  [M  `Or^:ҍ47+\M  D701{MtMuM]M  7^M  DY701zMvMwM_M  Y`M  `OrY,^:ҍD7+aM  -$~^P `Mer-~Ġs=1H7PdP  ~7fP  7eP fPdP cM  ]P `Merۨ~둭=َ7PhP  7jP  7iP jPhP ~M sl"]M `MeR"&17PM ffjY7M  7M MM M sM `MeE6+7PM ُ7M  7M MM kP s9nP  `O 97+gM JMKM  lMnMoMhMhM KMLM iM LMMM jM MMNM kM NMOM lM JMOM mM LMPM nM JMRM oM KMSM pM RMUM qM MMWM rM XMWM sM YMXM  MMrMtM ZM\M uM \M]M vM ]M^M wM ^M_M xM _MOM yM OMZM zM ^MaM {M \McM M YM~M M YMM lP NMkP mP MMkP \P 11Cr(&ChemDraw can't interpret this label.  #    8"Arial C|w|wgw C -. -- -- - II --- VV -- --  J -- - -  -- -  -- - -- -J -- -\ )  ---\ )  -- - H -- - H-  -- -  -- --   -- --  A -- - A-  --- A5 s -- -1` -- - 1 -- -1I  -- -2H`H -- -}xoja\ - -- ----$-- --0E -- ----$!G/G0F1-- ----(,-- $('-.--'-- $)*--#-- $%&-- - - ' -- -. ] ' -- - - ' --- 8 ' -- -0  ' -- ---- $---- $---- $---- $-- --  -- $   ---- $  ---- $---- $--  t-. -. t t"Arial |w|wgw -.!O t-.   -. -.-.!T-.2-.!B2-.T-.!DT-.x-.!Px-.-.!S-.-.!O-.   -. -.-.!O-.   6-. -.66-.!O6-.    -. -.  -.!M -. -.!e -.    -. -.  -.!M -. -.!e -.    -. -.  -.!M -. -.!e -.    n-. -. n n-.!M n-. -.!e -.   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S S-.!1 S-. o-.!3 o-.  -. -.-.!O-.  &CDIFVjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8  LF Kr-$$$$xf  `  xXX Pe(XX dd'`5v~?5ArialP5v~?5$$PJM xst7KM yslt7LM zs7MM {slz701PiMqMjMNM |sz701PjMkMOM } ݸ701yMkMlMxMPM ~sQM  `O}H~-7+RM ݷ1h7SM sRh7UM #S\VM `OTBDPSy#;`V7_7PP  L\P  `O2XVlYbP`7+P nMH7P ^OP `Sifƻ^O:ULVS7+P )?7P nMX:7P ܺ+,37P K(X:7P K(H7P ܺ_O7P 2?7P J37P 2&7P )&7P J37P #53Y7P WL7P J``7P e7P  7P PP P PP P PP P PP P PP  PPPP PP P PP  PPP PP P PP  PPP PP P PP  PPPP PP P PP  PPP PP P PP  PPP PP P PP P PP P PP P PP WM s7XM sll7YM s7ZM  [M  `Or~*ҵi7+\M  D701{MtMuM]M  7^M  DYt701zMvMwM_M  Yt`M  `OrY,q~q*ҵ~yx7+aM  -$hbM `Mer-kf]@Mj7PaP  h7cP  7bP cPaP cM  dM `Merۨ@z7PeP  7gP  7fP gPeP ~M sl"]M `MeR"S33A7PM ffY7M T% 7M MM M sM `Me;-87PM ٲ7M T% 7M MM P &CDIFsl[7P ؚ=QP `Me>=T/G0S7PP fQ7P  7P PP gM JMKM  lMnMoMhMhM KMLM iM LMMM jM MMNM kM NMOM lM JMOM mM LMPM nM JMRM oM KMSM pM RMUM qM MMWM rM XMWM sM YMXM  MMrMtM ZM\M uM \M]M vM ]M^M wM ^M_M xM _MOM yM OMZM zM ^MaM {M \McM M YM~M M YMM P SMP  oMPP PP P s9P  `O&aϝ7+P NMP P MMP \P 13w=Jxx)&ChemDraw can't interpret this label.>)&HDMHCGRTS6  x ( `2# x$  y$z$  {# |"q}%~"]0$&"6$ $ !$!!  1 ! 1" 1 $ "%!$ -$a#         O OTBDPS OOMeMeMeMeMeO `` &%&#b `` #;"L#9x `` "/!"4\ `` "/!"4i ``  \Q N ``    `` $n"#"$l# `` &!%!&#" `` %:$%3 `` ##Q# T  '`L&e'c13Arial2&ZDMHCp@tw8wMwp@x@SwHSwH&. MDLSKXY Ariald  h EAAriald13 4!% iEE!% iE䁐E!% ҬpEE!% lxE䁐E!% lxEE!% ҬpEʼnE!O% ҬpEAE!% ?aEuE!% 3aEE! OTBDPS(!O% YEE!% oME2XE!Si% QEvE!% GE͋E!% wDE2XE!% ?Ee:E!% wDEE!% oMEE!% QEe:E!% GEE!% L@EE!% I8EE!% I8E͋E!% L@EɈE!% WEiE!% OE+E!% <\EYE!% f_EE!  ' ' ' ' '(. ' '(. ' '(. ' ' (. '  ' (. '  ' (. '  ' ' ' '"4 OTBDPS6=  YEE<"!% rEE!% E䁐E!% EE!O% wxE$E!% wxEDE!% ҬpETŀE!% hEDE!O% hE$E!Me!% aEĀE!  ')"4Me6=  aETŀE<,!Me!% EĀE!  ')"4Me6=  !ETŀE<-!Me!% ̋EE! CTE '"4Me6=  ͋E䁐E<.!Me!% E@E! CTE '"4Me6=  EAE</!% hYE䁐E!Me!% SEE!  '"4Me6=  SEdE<1!O% EAE '(. ' ' ' ' ' '( ' ' '  '  '  ' (. '  ' ' ' ') ' )R ') ') '  '  '(. ' ') ')`&DARC-F1CHEMDRAW 4.5Microsoft Wo010402002856*C  C w  C Q C w C C  O  C YC WQ C [Q C w  C Q O  C Z C C ZO C w O [C BC V C \C  C w O C  !Si 'C " &C f C @k C f* C *! C k C j #C A"$ C j# %C $& C A% C B()*C h'C -'C I'$$$$--ObjInfo1CONTENTS| _1047670223G4!mA. tx0xOle 0VjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8  LF Kr-$$$$xf  `  xXX Pe(XX dd'`5v~?5ArialP5v~?5$$PJM xst7KM yslt7LM zs7MM {slz701PiMqMjMNM |sz701PjMkMOM } ݸ701yMkMlMxMPM ~sQM  `O}H~-7+RM ݷ1h7SM sRh7UM #S\VM `OTBDPSy#;`V7_7PP  L\P  `O2XVlYbP`7+P nMH7P ^OP `Sifƻ^O:ULVS7+P )?7P nMX:7P ܺ+,37P K(X:7P K(H7P ܺ_O7P 2?7P J37P 2&7P )&7P J37P #53Y7P WL7P J``7P e7P  7P PP P PP P PP P PP P PP  PPPP PP P PP  PPP PP P PP  PPP PP P PP  PPPP PP P PP  PPP PP P PP  PPP PP P PP P PP P PP P PP WM s7XM sll7YM s7ZM  [M  `Or~*ҵi7+\M  D701{MtMuM]M  7^M  DYt701zMvMwM_M  Yt`M  `OrY,q~q*ҵ~yx7+aM  -$hbM `Mer-kf]@Mj7PaP  h7cP  7bP cPaP cM  dM `Merۨ@z7PeP  7gP  7fP gPeP ~M sl"]M `MeR"S33A7PM ffY7M T% 7M MM M sM `Me;-87PM ٲ7M T% 7M MM P sl[7P ؚ=QP `Me>=T/G0S7PP fQ7P  7P PP gM JMKM  lMnMoMhMhM KMLM iM LMMM jM MMNM kM NMOM lM JMOM mM LMPM nM JMRM oM KMSM pM RMUM qM MMWM rM XMWM sM YMXM  MMrMtM ZM\M uM \M]M vM ]M^M wM ^M_M xM _MOM yM OMZM zM ^MaM {M \McM M YM~M M YMM P SMP  oMPP PP P s9P  `O&aϝ7+P NMP P MMP \P 13w=Jxx)&ChemDraw can't interpret this label.ObjInfo35CONTENTS _1047812153>:8!mA. 0xKxOleP\8 $      !"#)*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_efghijklmnopqrstuvwxyz{|}~  B5 $$$$xf  `  xXX Pe(XX dd'`CArialYQC$$ZQJM 9st7KM :slt7LM ;s7MM <slz701WQiMqMjMNM =sz701VQjMkMOM > ݸ7PM ?sQM @ `O}7+RM Aݷ1h7SM BsRh7UM C#S\vP D`OHy#;`R_7+WM Es7XM Fsll7YM Gs7~M Hsl"]M I`MeR"7[QM JffY7M KT% 7M LMM M MsM N`Me7\QM Oٲ7M PT% 7M QMM {P Rsl[7}P SswbOP T`MeمwFRER7]QP UYO7P V 7P WPP gM XJMKM  lMnMoMhMhM YKMLM iM ZLMMM jM [MMNM kM \NMOM lM ]JMOM mM ^LMPM nM _JMRM oM `KMSM pM aRMUM qM bMMWM rM cXMWM sM dYMXM  MMrMM eYM~M M fYMM |P gSM{P  oM~P~P h{P}P NQ j wPQ l `Or]}qq7+OQ kOMNQ UQ ms9XQ p `O49ޗ49ޝ7+VQ nNMUQ WQ oMMUQ \P i14wx&ChemDraw can't interpret this label.ObjInfo79%CONTENTSK _1047900625K<!mA. rxpxOle &VjCD0100ChemDraw 6.08   $$$$xf  `  xXX Pe(XX dd'`JArialQJ$$QDN ZMO7EN ZO7FN ZSC7GN Z67HN ZM67IN ZSC7JN ZSCKN `OMeV?AT7QN 3LC=  `O?AG7+N f;O7N \D 7N NN N NN LN ZLSCP  `O2?AG7+NN Zc*7PN Zc*QN `Br̹+#+7#+\N ZMn^N `OTBDPS3n!!7 QYP LfP  `O23fv!7+ZP f@,7[P ffP `Sǐf"7+\P Nf7]P l37^P fA7_P f3H7`P 8fA7aP 8l37bP zx7cP zx7dP Gf7eP zS*7fP zS*7gP f̌7hP ̌7iP f337jP Ľ7P  7kP PYP lP YP[P mP ZP[P nP [P\P oP ZP]P  tPmPpPpP ]P^P qP ^P_P  pPrPrP _P`P sP `PaP  rPtPtP ZPaP uP \PbP  zPnPvPvP bPcP wP cPdP  vPxPxP dPeP yP ePfP  xPzPzP \PfP {P [PgP |P gPhP }P gPiP ~P gPjP O ZGDP7O Zr\7O Z4i7O ZL4iO `Me2egs7!QO @33i7O e 7O OO O ZɬuO `MePrs7"QO 3fu7O e 7O OO RN DNEN  WNSNSN ENFN TN FNGN  YNSNUN[NUN GNHN VN HNIN  ZNUNWNXNWN  INDN XN  INJN YN  FNLN ZN  NNHN [N  GNPN ]N NN\N O OO O OO  OOOO OO O OO P LNO #QP ZM̡7P Z̡7P ZS7P Zۈ7P ZMۈ7P ZS7P ZSP `OMeV7$QP 3LQ ! `Oܑ7+P f;7P  7P PP P  PP P "ZLSP #`OH27+P $Zc|7P %Zc|P &`Br̺}u}7#+P 'ZMnoP (`OTBDPS3nsLs7%QP )LfoQ P `O23fvlms7+P *n+L\7P + xcQ Q`Sifxc`h7+P ,)̐QS7P -nM7P .F7P /KhM7P 0Kh+L\7P 1xc7P 2rQS7P 3E{F7P 4r?v:7P 5)̐?v:7P 6F7P 7#l7P 8W˂`_`7P 9}s7P :$=:y7Q ; 7P <QP P =PP P >PP P ?PP P @PP  PPPP APP P BPP  PPP CPP P DPP  PPP EPP P FPP  PPPP GPP P HPP  PPP IPP P JPP  PPP KPP P LPP Q MPP Q NPP Q OPP P RZGD7P SZr7P TZ47P UZɬP V`MeP7&QQ W3f7Q X 7Q YQQ P ZZL4P [`Me27'Q Q \@337 Q ] 7 Q ^ Q Q P _PP  PPPP `PP P aPP  PPPPP bPP P cPP  PPPPP dPP P ePP P fPP P gPP P hPP P iPP P jPP P kPP P lPP  PPPP mPP P nPP P o 8@@E&ChemDraw can't interpret this label.P p 7&ChemDraw can't interpret this label.ObjInfo;='CONTENTS( _1047809654@!mA. p.xPxOle `VjCD0100ChemDraw 6.0qMicrosoft Word - H:\My Documents\John's Folder\Publications\Jesterone\submission files\JesteroneOMicrosoft Word8   +IL# C$$$$xf  `  xXX Pe(XX dd'`U+1-rArialPU+1-r$$PJM A 7KM B 7LM C( qQ7MM D701PiMqMjMNM E701PjMkMPOM FCfqQ701PkMPlMPM GqQQM H `OuqScȶ.7+RM IJf {7SM J( z7UM KJnvP L`OHxrfckq7+WM M( 17XM N7YM O( !7~M PM Q`Me>hA j/7PM R7M S7<7 7M TMM M U!M V`MeuScxȶu7PM W77M X7<7 7M YMM {P Zn7}P [( daP \`Meddj>Wfc7PP ]" a7P ^85< 7P _PP gM `JMKM  lMnMoMhMhM aKMLM iM bLMMM jM cMMNM kM dNMOM lM eJMOM mM fLMPM nM gJMRM oM hKMSM pM iRMUM qM jMMWM rM kXMWM sM lYMXM  MMrMM mYM~M M nYMM |P oSM{P  oM~P~P p{P}P P r7P v`H1C֯-n֣7PP333s+P PPPP sOMP P t7 #P w`OHC =~o7+P uOMP P xDaP z`H2Gԧ nұ/An atom in this label has an invalid valence.7PPY٩+P PPPP yNMP P {/P ~ `OSc 7+P |NMP P }MMP \P q 37/<^( 0-/ٕ&ChemDraw can't interpret this label.VjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8  39 ,$$$$xObjInfo?AaCONTENTSo_1047676555D!mA. }xxOle bVjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8   U$$$$xf  `  xXX Pe(XX dd'`>ArialO>$$O w.N0t7 x}z x7 y~aۥs z `O~e>p@^p@eu7+ {>.^ | `O>N[\a7+ }<0Ă ~ `O<e]7+ G<72This atom is very close to another atom or bond. .N7 G8c7 .Nȩ2L `CH34ը7! jt8c# `CH3Jx8Kqz7& ,ՔCL*  `O,cHIN7+( ^A7+ .N^A7/ P92<  `H0lJ/yo0yo57+1 PLJ4L `Me2GIU7OJL 3`= 7O VGJ7IL JLO = ͂z< 72This atom is very close to another atom or bond.? `C  `O,PmEPmE!7+A d{*7E s?3L `Megv#pw7OLL r\97NL 3`= 7ML NLLL N cݝ]%P  `Hc"$)7+Q 8fJ-7S K WoI701T[]lU :oS/W  `O:OW+@P],@W]17+X [`  `O^pGW!G^! 7+Z ׊bS\Vj  `OjfR\_`S\f`X7+\ 5fbC7a ֔vJ7b q:7d с)77f t*7h _:701TVik EoI7m q@Y7o űH%i7q QVhv `CH3YeTf\w7s WC1ny1L `CH3=G1Nv@wI7 nR  `HԶrOlQsV7+ 1 ]9  `H16]5#8]5#=7+;B unrl7B [c7 ;BB  >B    ;B  ;B  >B             "  " ! %  =f  @gR@ =? 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S 鋐*飉C# B:DJ@V  A`%i>BΪ Ca9!=A@y/*H\PB jc qFQtBU2!9ALPB&!;>ά{{ +b,AAȏR 9KY 1'ˊ{AbSps?>>7 r){,ظ:nbiaɤRk);(,`|אb!?v)ބ+ҽn7]nd &~/5-:هDԩG.ߏBa7wM4&TJA&[~HwƖԩ+mE1Ygg>#>/%ȇd쑸MY>ץ/؜ӳWrt>wy SYGz*U2)ƻ$ޜҘ)l1]f+ȕ7R|1X~/EIȞ/FǤ)m ŘәopcK% vm5uѳxȇ Z-QZv佶YĬ`ccKiAny-k1dq]2@'cDF1ClB MH2wXAfOA{A _%O@0@~m'&xKcA߲;]cNFւZOdʛ̙씙e\Ʊ5k4KϦ 9 6q[(eo<Wcc Asdl̩fy'qo?o'Їf4>&<*c`lgR'q5/砧el 3Vp/4g1)LY^-e0ƶ?lAOx=e7ƤOu2U~T񊌍EH=DZ5a|pB)s%56d=u;S2EWgı 6řβuv^m7rm=r{v=lRFrjH}Ni#+u c Ve.˯Ddʬ$3ŹRQWduO2cX&&؄+ ᏬY5_@ٿ`r]Lddt$(`SoA*kձM%q uX~j!מ%̮:nթ]έf3pK\D/+0g+ 6-r)g{9 9b}J .77݃Gۏ/qW7u[$2BGt(ʭSJnp/?*m Y7Nn1 c=K\k7ۛvH[L5zbδsTO8""!،l#B[6H;PSa?S^ߴ?W,ܴyzg:o5lZ :\}l}1""g|H\~={oƸ{io3xho?^a_~9{c|wօ ֬bxwEeovW|f}CdwE~eqMm:sTn]To}݄\wWۣ{x+^YYAuhIgԹG6f;w+vjy=O]E pnqcl&Й3{\i.Y Mv͈jӮ&%!Od"A~ԱoNzgɵԷcYFsej4@RH䲻KeϺyfW:P4PRINTCE7ObjInfoFcCONTENTSd_1047670109I!mA. xx     )*!"#$%&'(M+,-./N123456789:;<=>?@ABCDEFGHIJKLOQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz   I  h8"Arial C|w|wgw C -. -- -- -0 !  ---* !  -- -U 2 !  -- -2 2U !  -- -20 2!  -- -2!  -- -!  -- - Q !  --- Q !  -- -{!  -- -M 2 !  -- -R{!  -- -U q1 2!  -- -U q1 !  -- -1 U !  ---@ ] !  -- -Y33!  -- -5Y3!  -- -Y5!  -- -Z!  -- - - -- ----$-- --@XG -- ----$G:WXYG-- ----P<T=-- $9P;O?U=V--EGOK-- $EEGDNQLR--;RKZ-- $P:R9]M[N-- -@  U O\ -- -V  O\ -- --<<-- $<><:--GE-- $HJEC--SN-- $SUN L --^ W-- $_aW U -- --) <* <-- $:( <' >, <- --! 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I&CDIFVjCD0100ChemDraw 6.0UMicrosoft Word - E:\Porco Group\Yongbo\jesterone paper\v Supporting Information.doc8  39 ,$$$$xf  `  xXX Pe(XX dd'`fArialoPf$$pPJM Hs̊7KM Isl̊7LM Js7MM Kslz701mPiMqMjMNM Lsz701lPjMkMOM M 701yMkMlMxMPM NsQM O `Og[+xg[+x7+RM Pݿ1~7SM QsR~TM R`BrمΒw7#+UM S#SrVM T`OHy#;vhu7+WM Us7XM Vsll7YM Ws7ZM X [M Y `OrVV7+\M Z D701{MtMuM]M [ 7^M \ DY701zMvMwM_M ] Y`M ^ `OrY,7+aM _ -$~^P ``Mer-t7qPdP a ~7fP b 7eP cfPdP cM d ]P e`Merۨ7rPhP f 7jP g 7iP hjPhP ~M isl"]M j`MeR"7sPM kffjY7M l 7M mMM M nsM o`Me7tPM pُ7M q 7M rMM gM sJMKM  lMnMoMhMhM tKMLM iM uLMMM jM vMMNM kM wNMOM lM xJMOM mM yLMPM nM zJMRM oM {KMSM pM |RMUM qM }MMWM rM ~XMWM sM YMXM  MMrMtM ZM\M uM \M]M vM ]M^M wM ^M_M xM _MOM yM OMZM zM ^MaM {M \McM M YM~M M YMM kP s9nP  `OgdVgdV7+lP NMkP mP MMkP \P 23&ChemDraw can't interpret this label. &$DMHCGRTSf  x ( `2#H$I%PJ$ K# L#M&pN"P%PQ#S%P!U$"V%P#W" X!a Z [!a\"] _ !d$$i&p#n$0!stuvwxyz{ | } ~     OBr OH OOMeMeMeMeO `` &O&;&  `` %R%L% `` #<T#P #$ `` " Y"L "!  `` "^"L" `` !` !  `` !!}e !! 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